Metin Yazar

 

20191007_160804.jpg (152 KB)       Dr. Metin YAZAR

I received my Bachelor of Science and Master of Science degrees from the Molecular Biology and Genetics Department of Istanbul Technical University. I also obtained my Ph.D. degree in Bioengineering from Marmara University working in in Computational Biology and Bioinformatics Research Group. Now I am a Postdoctoral Fellow at the School of Computer Science at the University Collage of Dublin in Ireland.

During my Master's degree, I worked on the aetiopathology of autoimmune diseases. We chose SLE and SSc as model autoimmune diseases to study the relationship between autoimmunity and anti-HLA antibodies. In the PhD studies, I have worked on investigating the functional and structural effects of cancer-associated variants on proteins and building a predictive machine learning classifier to classify the functional effects of cancer-associated variants. My main areas of interest are computational biology, cancer genomics, systems biology.

Journal Articles

  • Oktem E, Demir U, Yazar M.*, Arga KY. (2023). Three candidate anticancer drugs were repositioned by integrative analysis of the transcriptomes of species with different regenerative abilities after injury. Comput Biol Chem. 2023 Jul 21;106:107934. (Q1)
  • Oktem EK., Yazar M.* (2022). Drug Repositioning Identifies Six Drug Candidates for Systemic Autoimmune Diseases by Integrative Analyses of Transcriptomes from Scleroderma, Systemic Lupus Erythematosus, and Sjogren's Syndrome. OMICS: A Journal of Integrative Biology. 2022 Dec;26(12):683-693. (Q2)
  • Kubat Oktem E., Aydin B., Yazar M.*, Arga KY. (2022). Integrative Analysis of Motor Neuron and Microglial Transcriptomes from SOD1G93A Mice Models Uncover Potential Drug Treatments for ALS. Journal of Molecular Neuroscience. 2022 Nov;72(11):2360-2376. (Q2)
  • Yazar M.*, Ozbek P. (2022). Assessment of 13 in silico pathogenicity methods on cancer-related variants. Computers in Biology and Medicine. 2022 Jun; 145:105434. (Q1)
  • Yazar M.*, Ozbek P. (2021). In Silico Tools and Approaches for the Prediction of Functional and Structural Effects of Single-Nucleotide Polymorphisms on Proteins: An Expert Review. OMICS: A Journal of Integrative Biology. 2021 Jan;25(1):23-37. (Q2)
  • Yazar M.*, Ozbek P. (2020). Revisiting allostery in CREB-binding protein (CBP) using residue-based interaction energy. Journal of Computer-Aided Molecular Design. 2020 Sep;34(9):965-974. (Q2)
  • Öktem EK., Yazar M.*, Gulfidan G, Arga KY. (2019). Cancer Drug Repositioning by Comparison of Gene Expression in Humans and Axolotl (Ambystoma mexicanum) During Wound Healing. OMICS: A Journal of Integrative Biology, 2019 Aug;23(8):389-405. (Q2)
  • Pamuk ON., Gurkan H., Pamuk GE., Tozkır H., Duymaz J., Yazar M*. (2017). BLK pathway-associated rs13277113 GA genotype is more frequent in SLE patients and associated with low gene expression and increased flares. Clinical Rheumatology. 2017 Jan;36(1):103-109. (Q1)
  • Tozkır H., Pamuk ÖN., Duymaz J., Gürkan H., Yazar M.*, Sarı G., Tanrıkulu H., Pamuk GE. (2016). Increased frequency of class I and II anti-human leukocyte antigen antibodies in systemic lupus erythematosus and scleroderma and associated factors: a comparative study. International Journal of Rheumatic Diseases, 2016 Dec;19(12):1304-1309. (Q3)
  • Gurkan H., Tozkır H., Goncu E., Ulusal S., Yazar M.* (2015). The relationship between methylenetetrahydrofolate reductase c.677TT genotype and oligozoospermia in infertile male patients living in the Trakya region of Turkey. Andrologia. 2015 Nov;47(9):1068-74. (Q2)
  • Sarı G., Yazar M.*, (co-first author), Tozkır H., Duymaz J., Gürkan H. (2014). Identification of a novel HLA-A*26 allele, HLA-A*26:01:36, in a Turkish family by sequence-based typing. Tissue Antigens, Dec;84(6):580-1. (Q3)
  • Pamuk ON., Tozkır H., Uyanık MS., Gurkan H., Sarıtas F., Duymaz J., Donmez S., Yazar M.*, Pamuk GE. (2014). PECAM-1 gene polymorphisms and soluble PECAM-1 level in rheumatoid arthritis and systemic lupus erythematosus patients: any link with clinical atherosclerotic events?, Clinical Rheumatology, 33, 1737–1743. (Q1)
 
   


Proceedings

  • Yazar M.*, Ozbek Sarıca P. (2022). Pathogenicity prediction of cancer-related variants with protein sequence, structure, dynamics-based features. 8th International BAU Drug Design Congress, 15-17 December 2022, Istanbul, Turkey.
  • Yazar M.*, Ozbek Sarıca P. (2021). Comparison of the performances of in silico pathogenicity prediction tools on cancer-related variants. 14th International Symposium on Health Informatics and Bioinformatics (HIBIT2021), 10-11 September 2021, Virtual.
  • Yazar M.*, Ozbek Sarıca P. (2019). Identification of allostery in CREB-Binding Protein via using pairwise residue interaction energy method. 7th International BAU Drug Design Congress, 19-21 December 2019, Istanbul, Turkey.
  • Yazar M.*, Ozbek P. (2018). Comparison of allosteric pathway identification of CREB-binding protein using computational methods. 6th International BAU Drug Design Congress, 13-15 December 2018, Istanbul, Turkey.
  • Yazar M.*, Serçinoğlu O., Ozbek Sarıca P. (2018). Comparison of computational allosteric pathway identification methods. International Conference on Applied Mathematics, Modeling and Life Sciences, 03-05 October 2018, Istanbul, Turkey.
  • Duymaz J., Yazar M.*, Taş M., Kahraman B., Gürkan H., Tozkır H. (2015). Yeni bir HLA-B polimorfizmi (A novel HLA-B polymorphism). 5th National Transplantation Immunolgy and Genetics Congress,15-19 April 2015, Antalya, Turkey.
  • Gürkan H., Eker D., Yazar M.*, Ulusal S., Tozkır H. (2014). Alfa Talasemi klinik ön tanılı hastalarda alfa globin geni yeniden düzenlenmelerinin araştırılması. (Investigations of Alpha Globin Gene Rearrangements in pre-diagnosed as alpha-thalassemia patients.) 11. National Medical Genetics Congress, 24-27 September 2014, Istanbul, Turkey. (oral presentation by Hakan Gürkan, in Turkish)
  • Göncu, E., Yazar, M.*, Tozkır, H., Gürkan, H., Uyanık, M.Ş., Demir, A.M. (2013). Evaluation of major variant of Philadelphia chromosome (P210) with Real-Time PCR and FISH methods in chronic myeloid leukemia patients. I.Heamatologic Genetic Symposium, 2-4 December 2013, İzmir, Turkey.
  • Gurkan H., Tozkır H., Vatansever-Ozbek U., Sarı.G, Yazar M*. (2013). A Complex Phenotype-Patient with de novo 16q21-q24.3 Duplication and 15q11.1-q11.2 Deletion. European Human Genetics Conferance, 8-11 July 2013, Paris, FRANCE, J02.46
  • Sarı G., Uçunoglu N., Gürkan H., Gulec-Yılmaz S., Yazar M.*, Dalan A. B., Topcu H., Timirci-Kahraman Ö., İsbir T. (2013). Comparative Analysis of FLT3-ITD Mutation and 17P13 Deletion in Chronic Lymphocytic Leukemia Patient. 25. National Biochemistry Congress, 3-6 September 2013, P145, İzmir, Turkey.
  • Yazar M.*, Buldur P.M., Kök F.N. Yapısı geliştirilmiş recombinant jelatin proteini üretimi ve gıda aromalarının mikroenkapsülasyonuna etkisi. (Structurally Enhanced Gelatin Protein Production and Effects of microencapsulation of food aromas.). International Food R&D Research Convention 03-04 June 2013, İzmir, Turkey (Project presentation by Metin Yazar, in Turkish)
  • Tozkır H., Duymaz J., Sağıroğlu T., Yazar M.*, Gurkan H., Sağıroğlu G., Üstündağ S. (2012). Renal Transplantasyon öncesi HLA antikorlarının belirlenmesinde “Luminex Single Antigen” testinin önemi. (Importance of 'Luminex Single Antigen' test in detection of HLA antibodies before kidney transplantation). IX. Turkey Organ Transplantation Organization Coordination Congress, 26-29 September 2012, Bursa, Turkey (oral presentation by Tozkır H., in Turkish)
  • Tozkır, H., Sağıroğlu, T., Duymaz, J., Yazar, M.*, Sağıroğlu, G., Gurkan, H., Tan S., Tekataş A., Üstündağ S. (2012). Böbrek transplantasyonu sonrası hastanın immünolojik olarak monitorizasyonunda donor spesifik antikor varğının tespiti. (Immunological Evaluation of Donor Specific Antibodies of patients after kidney transplantation). IX. Turkey Organ Transplantation Organization Coordination Congress, 26-29 September 2012, Bursa, Turkey.

This page updated by Compbio on 12.10.2023 16:18:29

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